Premium
Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation
Author(s) -
Zavodszky Eszter,
Vicinanza Mariella,
Rubinsztein David C.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.04.025
Subject(s) - autophagy , autophagosome , atg16l1 , microbiology and biotechnology , biogenesis , biology , organelle , transport protein , biochemistry , gene , apoptosis
Autophagy is a highly conserved intracytoplasmic degradation pathway for proteins, oligomers, organelles and pathogens. It initiates with the formation of a cup‐shaped double membrane structure called the phagophore. The membrane origin for autophagosomes has been a key question for the field. ATG9 and ATG16L1, or their yeast orthologues, are key proteins that regulate autophagosome biogenesis, and may be associated with distinct membrane sources. Here we review the biology of autophagy with a focus on ATG16L1 and ATG9, and we summarise the current knowledge of their trafficking in relation to autophagic stimuli and autophagosome formation.