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ING4 inhibits the translation of proto‐oncogene MYC by interacting with AUF1
Author(s) -
Lu Meiling,
Pan Chunyang,
Zhang Lantian,
Ding Chenhong,
Chen Fei,
Wang Qinwan,
Wang Kesheng,
Zhang Xin
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.04.004
Subject(s) - immunoprecipitation , messenger rna , translation (biology) , three prime untranslated region , k562 cells , untranslated region , microbiology and biotechnology , suppressor , biology , chemistry , cell culture , gene , biochemistry , genetics
The ING4 tumor suppressor plays a significant role in various cancer‐related cellular processes. AUF1 affects the stability and/or translation of multiple mRNAs via binding to an AU‐rich element in the 3′‐untranslated regions. In this study, we identify AUF1 as a novel and direct binding partner of ING4. mRNP immunoprecipitation assays indicated that ING4, AUF1 and MYC mRNA present in the same mRNP complex. ING4 suppressed MYC protein expression without altering MYC mRNA levels, and abolished the cell proliferation induced by AUF1 in K562 cells. These results suggest that ING4 may regulate MYC translation by its association with AUF1.