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Globular adiponectin modulates expression of programmed cell death 4 and miR‐21 in RAW 264.7 macrophages through the MAPK/NF‐κB pathway
Author(s) -
Subedi Amit,
Kim Mi Jin,
Nepal Saroj,
Lee Eung-Seok,
Kim Jung-Ae,
Sohn Dong-Hwan,
Song Kyung,
Lee Sung Hee,
Park Won Sang,
Jeong Byeong-Seon,
Park Pil-Hoon
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.03.040
Subject(s) - mapk/erk pathway , microbiology and biotechnology , paracrine signalling , programmed cell death , microrna , chemistry , adiponectin , signal transduction , nf κb , mitogen activated protein kinase , biology , apoptosis , receptor , biochemistry , endocrinology , gene , insulin resistance , insulin
MicroRNA‐21 and programmed cell death 4 (PDCD4), a downstream target of miR‐21, mediate diverse physiological responses. Here we demonstrate that globular adiponectin (gAcrp) modulates expression of miR‐21 and PDCD4 in RAW 264.7 macrophages. These effects were abrogated by inhibitors of ERK1/2, JNK or NF‐κB. Conditioned media collected from gAcrp‐stimulated RAW 264.7 macrophages caused similar effects as direct gAcrp treatment, showing the paracrine effect of gAcrp. These data indicate that gAcrp modulates the miR‐21/PDCD4 axis through the ERK and JNK/NF‐κB pathways in RAW 264.7 macrophages and further suggest that the miR‐21/PDCD4 axis may be a novel target mediating adiponectin‐induced biological responses.