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A crucial role for Lyn in TIMP‐1 erythroid cell survival signalling pathway
Author(s) -
Bridoux Lucie,
Etique Nicolas,
Lambert Elise,
Thevenard Jessica,
Sowa Marie-Line,
Belloy Nicolas,
Dauchez Manuel,
Martiny Laurent,
Charpentier Emmanuelle
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.03.032
Subject(s) - lyn , microbiology and biotechnology , tyrosine kinase , protein kinase b , kinase , proto oncogene tyrosine protein kinase src , chemistry , cancer research , cell growth , tyrosine protein kinase csk , signal transduction , biology , protein tyrosine kinases , biochemistry
TIMP‐1, a well‐known MMP inhibitor, displays other biological activities such as cell survival, proliferation and differentiation in hematopoietic cells. In this report, we investigated the role of the Src‐related kinase Lyn in TIMP‐1 induced UT‐7 erythroleukemic cell survival. We showed that (i) tyrosine 507 of Lyn was dephosphorylated and Lyn kinase activity enhanced by TIMP‐1, (ii) Lyn silencing suppressed TIMP‐1 anti‐apoptotic activity and (iii) Lyn was activated upstream the JAK2/PI 3‐kinase/Akt pathway. Our data suggest a novel role for Lyn in erythroid cell survival.