Premium
Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C‐induced cell death
Author(s) -
Yamashita Arisa,
Taniwaki Tatsuya,
Kaikoi Yuka,
Yamazaki Tetsuo
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.03.024
Subject(s) - endoplasmic reticulum , microbiology and biotechnology , chemistry , programmed cell death , cell , biochemistry , apoptosis , biology
The endoplasmic reticulum (ER) operates in adaptive responses to various stresses, dictating cell fate. Here we show that knockdown of the ER protein mitsugumin23 (MG23) enhances cell death induced by ultraviolet C (UVC), which causes DNA damage. The small heat shock protein αB‐crystallin (αBC) is identified as a MG23 binding molecule and its knockdown facilitates death of UVC‐exposed cells. Conversely, αBC lowered UVC sensitivity when expressed as an ER‐anchored form. Taken together, the results suggest that MG23 plays a protective role against UVC by accumulating αBC in the close vicinity of the ER.