Premium
The Trypanosoma brucei telomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family
Author(s) -
Gupta Sachin Kumar,
Kolet Liat,
Doniger Tirza,
Biswas Viplov Kumar,
Unger Ron,
Tzfati Yehuda,
Michaeli Shulamit
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.03.017
Subject(s) - small nucleolar rna , telomerase , biology , telomere , rna , gene , microbiology and biotechnology , non coding rna , trypanosoma brucei , genetics
Trypanosome protozoan parasites are the causative agents of devastating diseases. Trypanosome telomeres grow in an uncontrolled manner and the variant surface glycoprotein (VSG) genes are located in subtelomeric domains. The gene encoding telomerase reverse transcriptase (TERT) was identified and in this study, we describe the Trypanosoma brucei telomerase RNA (TER). TER RNA is bound by the core proteins of the C/D small nucleolar RNA (snoRNA) family and associates with the methyltransferase‐associated protein (MTAP), whose homologue binds to mammalian TER. Silencing of Tb TER resulted in telomere shortening. This is the first report of a TER that binds the C/D snoRNA core proteins.