Premium
Structure and assembly of the influenza A virus ribonucleoprotein complex
Author(s) -
Zheng Wenjie,
Tao Yizhi Jane
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.02.048
Subject(s) - ribonucleoprotein , reassortment , nucleoprotein , virology , biology , rna , virus , influenza a virus , viral replication , ribonucleoprotein particle , polymerase , genome , rna dependent rna polymerase , viral structural protein , gene , viral entry , genetics , covid-19 , medicine , disease , pathology , infectious disease (medical specialty)
The genome of influenza A viruses consists of eight segments of single‐stranded, negative‐sense RNA that are encapsidated as individual rod‐shaped ribonucleoprotein complexes (RNPs). Each RNP contains a viral RNA, a viral polymerase and multiple copies of the viral nucleoprotein (NP). Influenza A virus RNPs play important roles during virus infection by directing viral RNA replication and transcription, intracellular transport of the viral RNA, gene reassortment as well as viral genome packaging into progeny particles. As a unique genomic entity, the influenza A virus RNP has been extensively studied since the 1960s. Recently, exciting progress has been made in studying the RNP structure and its assembly, leading to a better understanding of the structural basis of various RNP functions.