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Extracellular matrix components: An intricate network of possible biomarkers for lysosomal storage disorders?
Author(s) -
Batzios Spyros P.,
Zafeiriou Dimitrios I.,
Papakonstantinou Eleni
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.02.035
Subject(s) - extracellular matrix , disease , lysosomal storage disorders , computational biology , pathogenesis , medicine , neuroscience , bioinformatics , biology , immunology , microbiology and biotechnology , pathology
Biomarkers are extremely important in the case of multisystemic diseases, such as lysosomal storage disorders (LSDs), which are often difficult to assess in clinical practice. Several studies demonstrated significant alterations in the expression of extracellular matrix (ECM) components in LSD patients, raising important questions in relation to their possible involvement in disease pathogenesis and providing evidence for their possible utility as disease biomarkers. This article provides an overview of the possible pathogenic correlations between LSDs and ECM. Data regarding the expression of these molecules are discussed. Finally, the possible implication of ECM components as therapeutic targets in this group of diseases along with the impact of the differential expression of these components in current LSD treatment will be critically addressed.