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Regulated unfolding of proteins in signaling
Author(s) -
Mitrea Diana M.,
Kriwacki Richard W.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.02.024
Subject(s) - mechanism (biology) , signal transduction , signaling proteins , function (biology) , microbiology and biotechnology , transduction (biophysics) , chemistry , biophysics , biology , computational biology , physics , quantum mechanics
The transduction of biological signals often involves structural rearrangements of proteins in response to input signals, which leads to functional outputs. This review discusses the role of regulated partial and complete protein unfolding as a mechanism of controlling protein function and the prevalence of this regulatory mechanism in signal transduction pathways. The principles of regulated unfolding, the stimuli that trigger unfolding, and the coupling of unfolding with other well characterized regulatory mechanism are discussed.