Premium
HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer
Author(s) -
Wang Sen,
Pang Tianyun,
Gao Min,
Kang Haixian,
Ding Weibin,
Sun Xiwen,
Zhao Yi,
Zhu Wei,
Tang Xudong,
Yao Yunhong,
Hu Xinrong
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.01.042
Subject(s) - eif4e , cancer research , transcription factor , cervical cancer , cell growth , eukaryotic translation , apoptosis , biology , translation (biology) , microbiology and biotechnology , cancer , medicine , messenger rna , gene , genetics
Increasing evidence has placed eukaryotic translation initiation factor 4E (eIF4E) at the hub of tumor development and progression. Several studies have reported that eIF4E is over‐expressed in cervical cancer; however, the mechanism remains elusive. The results of this study further confirm over‐expression of eIF4E in cervical cancer tumors and cell lines, and we have discovered that the transcription of eIF4E is induced by protein E6 of the human papillomavirus (HPV). Moreover, regulation of eIF4E by E6 significantly influences cell proliferation, the cell cycle, migration, and apoptosis. Therefore, eIF4E emerges as a key player in tumor development and progression and a potential target for CC treatment and prevention.