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Formation of alternative proteasomes: Same lady, different cap?
Author(s) -
Pick Elah,
Berman Tali S.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.01.014
Subject(s) - proteasome , atpase , aaa proteins , chemistry , ring (chemistry) , computational biology , microbiology and biotechnology , biochemistry , biology , enzyme , organic chemistry
Two groups have recently reported the activation of archeal 20S by a p97‐related double‐ring AAA+ ATPase complex, in a similar fashion to that reported for 19S. Since p97 is found in eukaryotes, the existence of a parallel setting in higher organisms is intriguing. Herein, we present supporting data and hypothesize that in eukaryotes, p97 and CSN form a promiscuous, hence hard‐to‐detect, “alternative cap”, enabling the prompt and precise elimination of particular substrates.