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Vimentin is a component of a complex that binds to the 5′‐UTR of human heme‐regulated eIF2α kinase mRNA and regulates its translation
Author(s) -
Chatterjee Sangeeta,
Panda Amaresh C.,
Berwal Sunil K.,
Sreejith R.K.,
Ritvika Charu,
Seshadri Vasudevan,
Pal Jayanta K.
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2013.01.013
Subject(s) - translation (biology) , messenger rna , five prime untranslated region , vimentin , heme , translational regulation , untranslated region , microbiology and biotechnology , three prime untranslated region , kinase , chemistry , biology , biochemistry , enzyme , gene , immunohistochemistry , immunology
The human heme‐regulated eIF2α kinase, also called the human heme‐regulated inhibitor (hHRI) is significantly up‐regulated particularly at the level of translation during stress. In this report we show that during lead‐stress, the regulation of hHRI mRNA translation is mediated through its 5′‐untranslated region (UTR) that interacts with specific trans‐acting factors. Further, vimentin has been identified as one of the trans‐acting factors that contribute to this regulation.