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Genome‐wide characterization of the relationship between essential and TATA‐containing genes
Author(s) -
Han Hyun Wook,
Bae Sang Hun,
Jung Yun Hwa,
Moon Jisook
Publication year - 2013
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.12.030
Subject(s) - tata box , gene , biology , genetics , tata binding protein , housekeeping gene , genome , saccharomyces cerevisiae , tata box binding protein , transcription factor , computational biology , promoter , gene expression , dna binding protein
Essential genes are involved in most survival‐related housekeeping functions. TATA‐containing genes encode proteins involved in various stress–response functions. However, because essential and TATA‐containing genes have been researched independently, their relationship remains unclear. The present study classified Saccharomyces cerevisiae genes into four groups: non‐essential non‐TATA, non‐essential TATA, essential non‐TATA, and essential TATA genes. The results showed that essential TATA genes have the most significant codon bias, the highest level of expression, and unique characteristics, including a large number of transcription factor binding sites, a higher degree in protein interaction networks, and significantly different amino acid usage patterns compared with the other gene groups. Notably, essential TATA genes were uniquely involved in functions such as unfolded protein binding, glycolysis, and alcohol and steroid‐related processes.