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Novel function of transthyretin in pancreatic alpha cells
Author(s) -
Su Yu,
Jono Hirofumi,
Misumi Yohei,
Senokuchi Takafumi,
Guo Jianying,
Ueda Mitsuharu,
Shinriki Satoru,
Tasaki Masayoshi,
Shono Makoto,
Obayashi Konen,
Yamagata Kazuya,
Araki Eiichi,
Ando Yukio
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.10.025
Subject(s) - transthyretin , glucagon , glucose homeostasis , endocrinology , medicine , alpha cell , homeostasis , pancreatic islets , alpha (finance) , chemistry , knockout mouse , islet , pancreas , diabetes mellitus , biology , insulin , beta cell , insulin resistance , receptor , construct validity , nursing , patient satisfaction
Although transthyretin (TTR) is expressed in pancreatic alpha (glucagon) cells in the islets of Langerhans, the function of TTR in pancreatic alpha cells remains unknown. In this study, by using TTR knockout (TTR KO) mice, we determined the novel role of TTR in glucose homeostasis. We demonstrated that TTR KO mice evidenced impaired recovery of blood glucose and glucagon levels. Lack of TTR induced significantly lower levels of glucagon in the islets of Langerhans. These results suggest that TTR expressed in pancreatic alpha cells may play important roles in glucose homeostasis via regulating the expression of glucagon.