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Signaling regulated endocytosis and exocytosis lead to mating pheromone concentration dependent morphologies in yeast
Author(s) -
Chou Ching-Shan,
Moore Travis I.,
Chang Steven D.,
Nie Qing,
Yi Tau-Mu
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.10.024
Subject(s) - exocytosis , endocytosis , microbiology and biotechnology , organelle , saccharomyces cerevisiae , mating of yeast , biology , vesicle , yeast , actin , pheromone , endocytic cycle , cell polarity , actin cytoskeleton , cytoskeleton , cell , secretion , membrane , biochemistry , genetics
Polarized cell morphogenesis requires actin cytoskeleton rearrangement for polarized transport of proteins, organelles and secretory vesicles, which fundamentally underlies cell differentiation and behavior. During yeast mating, Saccharomyces cerevisiae responds to extracellular pheromone gradients by extending polarized projections, which are likely maintained through vesicle transport to (exocytosis) and from (endocytosis) the membrane. We experimentally demonstrate that the projection morphology is pheromone concentration‐dependent, and propose the underlying mechanism through mathematical modeling. The inclusion of membrane flux and dynamically evolving cell boundary into our yeast mating signaling model shows good agreement with experimental measurements, and provides a plausible explanation for pheromone‐induced cell morphology.