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“η 6 ”‐Type anion–π in biomolecular recognition
Author(s) -
Chakravarty Suvobrata,
Sheng Zi-Zhang,
Iverson Bradley,
Moore Brian
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.10.017
Subject(s) - nucleic acid , folding (dsp implementation) , chemistry , ion , macromolecule , amino acid , function (biology) , type (biology) , crystallography , biophysics , biochemistry , biology , genetics , organic chemistry , electrical engineering , engineering , ecology
Theoretical and compelling experimental evidence indicates that the interaction between an anion and an aromatic π system when the anion is directly above the ring face (“η 6 ”‐type anion–π), can be attractive. This may play an important role in the formation and recognition of biomolecular structures. We examined high‐resolution structures of proteins and nucleic acids for the presence of “η 6 ”‐type anion–π. Though less frequent than its counterpart cation–π, “η 6 ”‐type anion–π is observed unambiguously, occurring in protein/nucleic acid loops and often involving conserved/coevolving sites in proteins, suggesting it plays an important role in macromolecular folding and function.