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An in vitro study of the role of β‐boswellic acid in the microtubule assembly dynamics
Author(s) -
Karima Oveis,
Riazi Gholamhossein,
Khodadadi Sirus,
Yousefi Reza,
Mahnam Karim,
Mokhtari Farzad,
Cheraghi Tayebe,
Hoveizi Elham,
Moosavi-Movahedi Ali Akbar
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.10.007
Subject(s) - microtubule , in vitro , tubulin , chemistry , microbiology and biotechnology , biophysics , biochemistry , biology
Structural integrity of microtubule protein (MTP) is pivotal for its physiological roles. Disruption of the MTP network is known to be involved in neurodegenerative disorders. The gum resin of plants of the boswellia species, with β‐boswellic acid (BBA) as the major component, has long been used in Ayurveda and Oriental Medicine to prevent amnesia. In the current study, we addressed the question whether BBA affects assembly dynamics behavior of tubulin. Our in vitro results revealed that BBA increases MTP length distribution and the polymerization rate of tubulin, moderately stabilizing it and diminishing both the critical concentration ( C c ) and the fraction of inactive tubulin ( F i ).