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The Junctional Adhesion Molecule‐B regulates JAM‐C‐dependent melanoma cell metastasis
Author(s) -
Arcangeli Marie-Laure,
Frontera Vincent,
Bardin Florence,
Thomassin Jeanne,
Chetaille Bruno,
Adams Susanne,
Adams Ralf H.,
Aurrand-Lions Michel
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.10.005
Subject(s) - metastasis , melanoma , adhesion , cancer research , cell adhesion , cell adhesion molecule , microbiology and biotechnology , chemistry , in vivo , biology , cancer , genetics , organic chemistry
Metastasis is a major clinical issue and results in poor prognosis for most cancers. The Junctional Adhesion Molecule‐C (JAM‐C) expressed by B16 melanoma and endothelial cells has been involved in metastasis of tumor cells through homophilic JAM‐C/JAM‐C trans‐interactions. Here, we show that JAM‐B expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with JAM‐C on tumor cells. We further show that this adhesion molecular pair mediates melanoma cell adhesion to primary Lung Microvascular Endothelial Cells and that it is functional in vivo as demonstrated by the reduced metastasis of B16 cells in Jam‐b deficient mice.