Premium
Role of poly(ADP‐ribose) polymerases in the regulation of inflammatory processes
Author(s) -
Bai Péter,
Virág László
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.09.026
Subject(s) - poly adp ribose polymerase , enzyme , inflammation , chemokine , immune system , microbiology and biotechnology , nitric oxide , proinflammatory cytokine , nitric oxide synthase , biology , chemistry , biochemistry , polymerase , immunology , endocrinology
PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation‐related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes.