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Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?
Author(s) -
Niki Etsuo
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.09.025
Subject(s) - reactive oxygen species , lipid peroxidation , reactive nitrogen species , chemistry , antioxidant , lipid oxidation , signal transduction , cell signaling , oxidative phosphorylation , oxidative stress , biochemistry
Oxidative modification of biologically essential molecules by reactive oxygen and nitrogen species (ROS/RNS) has been implicated in the pathogenesis of various diseases. At the same time, roles of ROS/RNS as physiological signaling messenger have been established. Lipid oxidation products also have two faces. It is argued that the radical scavenging antioxidants taken from diet or supplement may impair such beneficial effects of ROS/RNS and lipid oxidation products. However, it is unlikely that antioxidants impair physiologically important signaling, since the antioxidants do not scavenge signaling ROS/RNS nor do they inhibit the formation of signaling molecules. Lipid peroxidation products are not produced on purpose and inhibition of lipid peroxidation by antioxidants should be beneficial for maintenance of health and reducing disease risk.