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Equilibrium self‐association of tropomyosin
Author(s) -
Stafford Walter F.,
Lee Eunhee,
Graceffa Philip
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.08.035
Subject(s) - tropomyosin , tetramer , dimer , chemistry , monomer , ultracentrifuge , actin , trimer , biophysics , biochemistry , biology , polymer , organic chemistry , enzyme
It has recently been reported that tropomyosin exists exclusively as a dimer in physiological salt conditions. It is shown in the present work using analytical ultracentrifugation that, on the contrary, tropomyosin is in equilibrium between monomer, dimer and tetramer with a weak tendency to dimerize and tetramerize. Such a finding has consequences for the assembly of the tropomyosin–actin complex.
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