MiR‐136 promotes apoptosis of glioma cells by targeting AEG‐1 and Bcl‐2 | Zendy

Yang Yi | Zendy; Wu Jueheng | Zendy; Guan Hongyu | Zendy; Cai Junchao | Zendy; Fang Lishan | Zendy; Li Jun | Zendy; Li Mengfeng | Zendy

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MiR‐136 promotes apoptosis of glioma cells by targeting AEG‐1 and Bcl‐2

Author(s) -

Yang Yi,

Wu Jueheng,

Guan Hongyu,

Cai Junchao,

Fang Lishan,

Li Jun,

Li Mengfeng

Publication year - 2012

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2012.08.003

Subject(s) - glioma , apoptosis , microrna , cancer research , biology , microbiology and biotechnology , gene , genetics

MicroRNAs have the capacity to coordinately repress multiple target genes and interfere with biological functions of the cell, such as proliferation and apoptosis. Here we report that miR‐136 is downregulated in human glioma, and that the miRNA promotes apoptosis of glioma cells induced by chemotherapy. Two anti‐apoptotic genes, AEG‐1 and Bcl‐2, are identified as targets of miR‐136, and restoration of AEG‐1 or Bcl‐2 expression suppresses miR‐136‐enhanced apoptosis. Therefore, miR‐136 might play a tumor‐suppressive role in human glioma and thereby might represent a potential therapeutic strategy.

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