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Fetuin‐A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading
Author(s) -
Watson Kurt,
Koumangoye Rainelli,
Thompson Pamela,
Sakwe Amos M.,
Patel Tina,
Pratap Siddharth,
Ochieng Josiah
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.07.071
Subject(s) - microvesicles , secretion , adhesion , microbiology and biotechnology , chemistry , fetuin , tumor cells , biophysics , biochemistry , biology , cancer research , glycoprotein , microrna , organic chemistry , gene
Our goal in this study was to define the mechanisms by which fetuin‐A mediates the adhesion of tumor cells. The data show that in the absence of fetuin‐A, detached tumor cells secrete exosomes that contain most of the known exosomal associated proteins but lack the capacity to mediate cellular adhesion. In the presence of fetuin‐A, the cells secrete exosomes, which contain, in addition to the other exosomal proteins, fetuin‐A, plasminogen and histones. These exosomes mediate adhesion and cell spreading. Plasminogen is a participant in this novel adhesion mechanism. The data suggest that these exosomes play a role in tumor progression.