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E‐cadherin dysfunction in gastric cancer ‐ Cellular consequences, clinical applications and open questions
Author(s) -
Carneiro Patrícia,
Fernandes Maria Sofia,
Figueiredo Joana,
Caldeira Joana,
Carvalho Joana,
Pinheiro Hugo,
Leite Marina,
Melo Soraia,
Oliveira Patrícia,
Simões-Correia Joana,
Oliveira Maria José,
Carneiro Fátima,
Figueiredo Céu,
Paredes Joana,
Oliveira Carla,
Seruca Raquel
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.07.045
Subject(s) - cadherin , context (archaeology) , cancer , cell adhesion , cancer research , biology , germline mutation , mutation , gene , cell , genetics , paleontology
E‐cadherin plays a major role in cell–cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E‐cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E‐cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families.