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PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization
Author(s) -
Cheung Derek Hang-Cheong,
Kung Hsiang-Fu,
Huang Jun-Jian,
Shaw Pang-Chui
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.06.028
Subject(s) - telomerase , telomere , microbiology and biotechnology , function (biology) , telomerase reverse transcriptase , biology , chemistry , genetics , dna , gene
Telomerase recruitment to telomere is the prerequisite for telomere extension, but the proteins involved in this process are still largely unknown. PinX1 is a telomerase inhibitor and has been implicated in telomere maintenance. Silencing of PinX1 significantly reduced the localization of telomerase to telomere during mid‐late S phase, suggesting the involvement of PinX1 in the cell cycle‐dependent trafficking of hTERT to telomere. We also revealed that PinX1 mediated the chromosomal localization of hTERT during anaphase. This study revealed the role of PinX1 in telomerase function regulation by mediating its localization inside cells.