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Amadori‐glycated phosphatidylethanolamine up‐regulates telomerase activity in PANC‐1 human pancreatic carcinoma cells
Author(s) -
Eitsuka Takahiro,
Nakagawa Kiyotaka,
Ono Yuichi,
Tatewaki Naoto,
Nishida Hiroshi,
Kurata Tadao,
Shoji Naoki,
Miyazawa Teruo
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.06.027
Subject(s) - telomerase , amadori rearrangement , pancreatic cancer , cancer research , cancer , diabetes mellitus , cancer cell , endocrinology , glycation , medicine , oncology , biology , chemistry , biochemistry , gene
Several lines of experimental data have highlighted a key role of Amadori‐glycated phosphatidylethanolamine (Amadori‐PE) in the development of diabetic complications. Recent epidemiological studies suggest that diabetes mellitus could be a risk factor for some cancers. A characteristic of cancer cells is their immortal phenotype, and the enzyme telomerase contributes to the infinite replicative potential of cancer cells. The purpose of this study was to obtain new information about the effect of Amadori‐PE on the regulation of telomerase in PANC‐1 human pancreatic carcinoma cells. Amadori‐PE enhanced cellular telomerase in a time‐ and dose‐dependent manner by up‐regulating hTERT expression through induction of c‐myc . These results provide experimental evidence for a novel role of Amadori‐PE in linking diabetes and cancer.