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Syndecans play dual roles as cell adhesion receptors and docking receptors
Author(s) -
Kwon Mi-Jung,
Jang Bohee,
Yi Jae Youn,
Han Inn-Oc,
Oh Eok Soo
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.05.037
Subject(s) - syndecan 1 , receptor , microbiology and biotechnology , heparan sulfate , cell surface receptor , docking (animal) , cell , cell adhesion , biology , cell type , chemistry , biochemistry , medicine , nursing
Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra‐ and extracellular activities, potentially altering a variety of cell behaviors.