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Origin of non‐cardiac endothelial cells from an Isl1+ lineage
Author(s) -
Keenan Iain D.,
Rhee Hong Jun,
Chaudhry Bill,
Henderson Deborah J.
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.05.014
Subject(s) - progenitor cell , embryonic stem cell , biology , microbiology and biotechnology , progenitor , population , lineage (genetic) , endothelial stem cell , embryo , stem cell , genetics , gene , in vitro , medicine , environmental health
The cardiovascular system consists of many cell types with distinct embryonic origins. Cells from an Islet1 ( Isl1 )‐expressing progenitor population make a substantial contribution to the developing heart. We reasoned that cells derived from Isl1 ‐expressing progenitors might contribute more widely to the cardiovascular system. We show that cells derived from an Isl1 ‐expressing progenitor lineage make a wide contribution to the systemic vasculature and that embryos conditionally deficient for Rac1 within this cell population develop defects in the non‐cardiac vasculature. These data define new roles for Isl1 in the developing embryo and demonstrate a contribution of Isl1 ‐expressing progenitors to vascular endothelium in vivo.