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Crosstalk between TGF‐β and hedgehog signaling in cancer
Author(s) -
Javelaud Delphine,
Pierrat Marie-Jeanne,
Mauviel Alain
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.05.011
Subject(s) - crosstalk , hedgehog , signal transduction , hedgehog signaling pathway , transforming growth factor , biology , signalling pathways , cancer research , microbiology and biotechnology , neuroscience , physics , optics
Hedgehog (HH) and TGF‐β signals control various aspects of embryonic development and cancer progression. While their canonical signal transduction cascades have been well characterized, there is increasing evidence that these pathways are able to exert overlapping activities that challenge efficient therapeutic targeting. We herein review the current knowledge on HH signaling and summarize the recent findings on the crosstalks between the HH and TGF‐β pathways in cancer.