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BRCT domains: A little more than kin, and less than kind
Author(s) -
Gerloff Dietlind L.,
Woods Nicholas T.,
Farago April A.,
Monteiro Alvaro N.A.
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.05.005
Subject(s) - biology , dna , computational biology , function (biology) , microbiology and biotechnology , genetics
BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than 20 different proteins in the human genome. Interestingly, most BRCT‐containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain‐centric analysis can aid in the understanding of signal transduction events in the DNA damage response network.