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Perspective: Dynamics of receptor tyrosine kinase signaling complexes
Author(s) -
Mayer Bruce J.
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.05.002
Subject(s) - signal transduction , receptor tyrosine kinase , perspective (graphical) , receptor protein tyrosine kinases , snapshot (computer storage) , grb2 , tyrosine kinase , computational biology , microbiology and biotechnology , biology , computer science , artificial intelligence , operating system
Textbook descriptions of signal transduction complexes provide a static snapshot view of highly dynamic events. Despite enormous strides in identifying the key components of signaling complexes and the underlying mechanisms of signal transduction, our understanding of the dynamic behavior of these complexes has lagged behind. Using the example of receptor tyrosine kinases, this perspective takes a fresh look at the dynamics of the system and their potential impact on signal processing.