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4′‐Hydroxyflavanone suppresses activation of sterol regulatory element‐binding proteins and de novo lipid synthesis
Author(s) -
Miyata Shingo,
Inoue Jun,
Shimizu Makoto,
Sato Ryuichiro
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.04.060
Subject(s) - sterol regulatory element binding protein , fatty acid synthase , fatty acid synthesis , biochemistry , transcription factor , chemistry , steatosis , sterol , fatty acid , cholesterol , gene , biology , endocrinology
Sterol regulatory element‐binding proteins (SREBPs) are major transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here we show that 4′‐hydroxyflavanone (4′‐HF) impairs the fatty acid synthase promoter activity and reduces the activation of SREBPs and their target gene expression in human hepatoma Huh‐7 cells. Moreover, 4′‐HF suppresses de novo fatty acid and cholesterol synthesis. This study identifies 4′‐HF as an inhibitor of SREBP maturation and lipid synthesis, and provides evidence that 4′‐HF may have major potential as a pharmaceutical preparation against hepatic steatosis and dyslipidemia.