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Systems and synthetic biology of the vessel wall
Author(s) -
Frueh Jennifer,
Maimari Nataly,
Lui Ying,
Kis Zoltan,
Mehta Vikram,
Pormehr Negin,
Grant Calum,
Chalkias Emmanuel,
Falck-Hansen Mika,
Bovens Sandra,
Pedrigi Ryan,
Homma Taka,
Coppola Gianfillippo,
Krams Rob
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.04.031
Subject(s) - mechanotransduction , microbiology and biotechnology , coupling (piping) , computational biology , biology , synthetic biology , chemistry , neuroscience , materials science , metallurgy
Atherosclerosis is intimately coupled to blood flow by the presence of predilection sites. The coupling is through mechanotransduction of endothelial cells and approximately 2000 gene are associated with this process. This paper describes a new platform to study and identify new signalling pathways in endothelial cells covering an atherosclerotic plaque. The identified networks are synthesized in primary cells to study their reaction to flow. This synthetic approach might lead to new insights and drug targets.