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Hinge sequences as signaling agents?
Author(s) -
Stec Boguslaw
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.04.026
Subject(s) - hinge , signal transduction , microbiology and biotechnology , transformation (genetics) , domain (mathematical analysis) , computer science , biology , engineering , mathematics , genetics , structural engineering , mathematical analysis , gene
We report an unexpected finding of common structural principles in two unrelated signaling systems: the FAS death domain transformation that initializes the extrinsic apoptotic pathway and signaling by calmodulin bending. The location and design of the hinge is postulated to be a general principle for creating potential signaling event. We suggest that already existing tool can predict the existence of such a hinge and formulate the hypothesis that the internal instabilities designed into the hinge sequences are necessary devices in effective signaling events.