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Synthetic Biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production
Author(s) -
Wohlleben Wolfgang,
Mast Yvonne,
Muth Günther,
Röttgen Marlene,
Stegmann Evi,
Weber Tilmann
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.04.025
Subject(s) - synthetic biology , biosynthesis , modular design , metabolic engineering , antibiotics , secondary metabolite , combinatorial chemistry , computational biology , glycopeptide antibiotic , glycopeptide , protein biosynthesis , biochemistry , chemistry , biochemical engineering , biology , computer science , bacteria , engineering , genetics , gene , operating system , vancomycin , staphylococcus aureus
The supply of precursors, which are subsequently incorporated into the final product, is often already organized in a modular manner in nature and may directly be exploited for Synthetic Biology. Here we report examples for the synthesis of building blocks and possibilities to modify and optimize antibiotic biosynthesis, exemplary for the synthesis of the manipulation of the synthesis of the glycopeptide antibiotic balhimycin.