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Dynamics of TGF‐β/Smad signaling
Author(s) -
Zi Zhike,
Chapnick Douglas A.,
Liu Xuedong
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.03.063
Subject(s) - smad , context (archaeology) , r smad , signal transduction , transforming growth factor , biology , stimulation , mechanism (biology) , cell signaling , adaptation (eye) , function (biology) , microbiology and biotechnology , computational biology , neuroscience , receptor , genetics , growth factor , tgf alpha , physics , paleontology , quantum mechanics
The physiological responses to TGF‐β stimulation are diverse and vary amongst different cell types and environmental conditions. Even though the principal molecular components of the canonical and the non‐canonical TGF‐β signaling pathways have been largely identified, the mechanism that underlies the well‐established context dependent physiological responses remains a mystery. Understanding how the components of TGF‐β signaling function as a system and how this system functions in the context of the global cellular regulatory network requires a more quantitative and systematic approach. Here, we review the recent progress in understanding TGF‐β biology using integration of mathematical modeling and quantitative experimental analysis. These studies reveal many interesting dynamics of TGF‐β signaling and how cells quantitatively decode variable doses of TGF‐β stimulation.