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Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6
Author(s) -
Kamemura Kazuo,
Ogawa Mitsutaka,
Ohkubo Saki,
Ohtsuka Yasuhiro,
Shitara Yu,
Komiya Tohru,
Maeda Satoko,
Ito Akihiro,
Yoshida Minoru
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.03.060
Subject(s) - hdac6 , downregulation and upregulation , cytoplasm , metabolism , mitochondrion , chemistry , microbiology and biotechnology , biology , biochemistry , histone deacetylase , gene , histone
Mitochondria perform multiple functions critical to the maintenance of cellular homeostasis. Here we report that the downregulation of histone deacetylase 6 (HDAC6) causes a reduction in the net activity of mitochondrial enzymes, including respiratory complex II and citrate synthase. HDAC6 deacetylase and ubiquitin‐binding activities were both required for recovery of reduced mitochondrial metabolic activity due to the loss of HDAC6. Hsp90, a substrate of HDAC6, localizes to mitochondria and partly mediates the regulation of mitochondrial metabolic activity by HDAC6. Our finding suggests that HDAC6 regulates mitochondrial metabolism and might serve as a cellular homeostasis surveillance factor.