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Inhibition of bacterial adhesion to live human cells: Activity and cytotoxicity of synthetic mannosides
Author(s) -
Hartmann Mirja,
Papavlassopoulos Heike,
Chandrasekaran Vijayanand,
Grabosch Carsten,
Beiroth Femke,
Lindhorst Thisbe K.,
Röhl Claudia
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.03.059
Subject(s) - adhesion , microbiology and biotechnology , mannan , chemistry , cell adhesion , cytotoxicity , lectin , in vivo , bacteria , bacterial cell structure , polysaccharide , biochemistry , in vitro , biology , genetics , organic chemistry
Bacterial adhesion to glycosylated surfaces is a key issue in human health and disease. Inhibition of bacterial adhesion by suitable carbohydrates could lead to an anti‐adhesion therapy as a novel approach against bacterial infections. A selection of five α‐mannosides has been evaluated as inhibitors of bacterial adhesion to the polysaccharide mannan, as well as to the surface of live human HT‐29 cells. Cell toxicity studies were performed to identify the therapeutic window for a potential in vivo‐application of the tested carbohydrates. A previously published mannosidic squaric acid diamide was shown to be exceptionally effective as inhibitor of the bacterial lectin FimH.