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PIWIL4 regulates cervical cancer cell line growth and is involved in down‐regulating the expression of p14ARF and p53
Author(s) -
Su Chang,
Ren Zhong-Jie,
Wang Fang,
Liu Min,
Li Xin,
Tang Hua
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.03.053
Subject(s) - p14arf , carcinogenesis , cervical cancer , cancer , cancer research , apoptosis , cell growth , biology , cancer cell , cervical carcinoma , cell , cell culture , tumor suppressor gene , genetics
Recently, PIWIL4 has been identified as a functional protein involved in tumorigenesis. Cervical cancer is the second most prevalent form of cancer worldwide. The relationship between PIWIL4 and cervical cancer is still unknown. Here, we found that PIWIL4 is up‐regulated in human cervical cancer tissues in comparison to adjacent normal tissues, and it promotes cell growth and proliferation by inhibiting apoptosis through the p14ARF/p53 pathway. PIWIL4 can also promote the invasion of cervical cancer cells. These results suggest that PIWIL4 might play an oncogenic role in cervical cancer and be useful as a new therapeutic target in the future.