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The layout of a bacterial genome
Author(s) -
Képès François,
Jester Brian C.,
Lepage Thibaut,
Rafiei Nafiseh,
Rosu Bianca,
Junier Ivan
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.03.051
Subject(s) - genome , biology , gene , genetics , bacterial genome size , computational biology , dna replication , genome evolution , dna , transcription (linguistics) , linguistics , philosophy
Recently the mismatch between our newly acquired capacity to synthetize DNA at genome scale, and our low capacity to design ab initio a functional genome has become conspicuous. This essay gathers a variety of constraints that globally shape natural genomes, with a focus on eubacteria. These constraints originate from chromosome replication (leading/lagging strand asymmetry; gene dosage gradient from origin to terminus; collisions with the transcription complexes), from biased codon usage, from noise control in gene expression, and from genome layout for co‐functional genes. On the basis of this analysis, lessons are drawn for full genome design.