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Loss of mPer2 increases plasma insulin levels by enhanced glucose‐stimulated insulin secretion and impaired insulin clearance in mice
Author(s) -
Zhao Yue,
Zhang Ying,
Zhou Mengyi,
Wang Shiming,
Hua Zichun,
Zhang Jianfa
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.03.034
Subject(s) - medicine , endocrinology , insulin , insulin oscillation , biology , insulin receptor , metabolism , period (music) , carbohydrate metabolism , insulin resistance , physics , acoustics
The existence of peripheral oscillators has been shown, and they are critically important for organizing the metabolism of the whole body. Here we show that mice deficient in mPer2 markedly increase circulatory levels of insulin compared with wild type mice. Insulin secretion was more effectively stimulated by glucose, and alloxan, a glucose analogue, induced more severe hyperglycemia in mPer2 ‐deficient mice. Hepatic insulin degrading enzyme ( Ide ) displayed an obvious day and night rhythm, which was impaired in mPer2‐deficient mice, leading to a decrease in insulin clearance. Deficiency in mPer2 caused increased Clock expression and decreased expression of Mkp1 and Ide1 , possibly underlying the observed phenotypes and suggesting that mPer2 plays a role in regulation of circulating insulin levels.