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Tumor suppressor functions of FBW7 in cancer development and progression
Author(s) -
Wang Zhiwei,
Inuzuka Hiroyuki,
Zhong Jiateng,
Wan Lixin,
Fukushima Hidefumi,
Sarkar Fazlul H.,
Wei Wenyi
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.03.017
Subject(s) - suppressor , carcinogenesis , biology , cancer , ubiquitin , cancer research , knockout mouse , tumor suppressor gene , microbiology and biotechnology , function (biology) , gene , genetics
FBW7 (F‐box and WD repeat domain‐containing 7) has been characterized as an onco‐suppressor protein in human cancers. Recent studies have also shown that FBW7 exerts its anti‐tumor function primarily by promoting the degradation of various oncoproteins, through which FBW7 regulates cellular proliferation, differentiation and causes genetic instability. In this review, we will discuss the role of FBW7 downstream substrates and how dysregulation of Fbw7‐mediated proteolysis of these substrates contributes to tumorigenesis. Additionally, we will also summarize the currently available various Fbw7‐knockout mouse models that support Fbw7 as a tumor suppressor gene in the development and progression of human malignancies.