microRNA‐210 negatively regulates LPS‐induced production of proinflammatory cytokines by targeting NF‐κB1 in murine macrophages | Zendy

Qi Jianni | Zendy; Qiao Yu | Zendy; Wang Peng | Zendy; Li Shuqing | Zendy; Zhao Wei | Zendy; Gao Chengjiang | Zendy

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microRNA‐210 negatively regulates LPS‐induced production of proinflammatory cytokines by targeting NF‐κB1 in murine macrophages

Author(s) -

Qi Jianni,

Qiao Yu,

Wang Peng,

Li Shuqing,

Zhao Wei,

Gao Chengjiang

Publication year - 2012

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2012.03.011

Subject(s) - proinflammatory cytokine , tlr4 , lipopolysaccharide , transfection , regulator , inflammation , microrna , downregulation and upregulation , immunology , chemistry , microbiology and biotechnology , biology , biochemistry , gene

Ligation of TLR4 with LPS in macrophages leads to the production of proinflammatory cytokines, which are central to eliminate viral and bacterial infection. However, uncontrolled TLR4 activation may contribute to pathogenesis of inflammatory diseases such as septic shock. In this study, we found microRNA‐210 was induced in murine macrophages by LPS. Transfection of miR‐210 mimics significantly inhibited LPS‐induced production of inflammatory cytokines. In contrast, transfection of anti‐miR‐210 inhibitors increased LPS‐induced expression of proinflammatory cytokines. Furthermore, we demonstrated that miR‐210 targets NF‐κB1. Therefore, our data identify miR‐210 as a very important feedback negative regulator for LPS‐induced production of proinflammatory cytokines.

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