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SnoN in regulation of embryonic development and tissue morphogenesis
Author(s) -
Zhu Qingwei,
Luo Kunxin
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.03.005
Subject(s) - morphogenesis , microbiology and biotechnology , biology , carcinogenesis , embryonic stem cell , embryogenesis , context (archaeology) , signal transduction , embryo , genetics , cancer , gene , paleontology
SnoN (Ski‐novel protein) plays an important role in embryonic development, tumorigenesis and aging. Past studies largely focused on its roles in tumorigenesis. Recent studies of its expression patterns and functions in mouse models and mammalian cells have revealed that SnoN interacts with multiple signaling molecules at different cellular levels to modulate the activities of several signaling pathways in a tissue context and developmental stage dependent manner. These studies suggest that SnoN may have broad functions in the embryonic development and tissue morphogenesis.