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Protein folding by ‘levels of separation’: A hypothesis
Author(s) -
Greene Lesley H.,
Grant Terri M.
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.02.040
Subject(s) - folding (dsp implementation) , protein folding , separation (statistics) , mechanism (biology) , range (aeronautics) , protein tertiary structure , chemistry , chemical physics , statistical physics , biological system , computational biology , computer science , biology , physics , materials science , biochemistry , engineering , machine learning , quantum mechanics , electrical engineering , composite material
The protein folding process has been studied both computationally and experimentally for over 30 years. To date there is no detailed mechanism to explain the formation of long‐range interactions between the transition and native states. Long‐range interactions are the principle determinants of the tertiary structure. We present a theoretical model which proposes a mechanism for the acquisition of these interactions as they form in a modified version of ‘degrees of separation’, that we term ‘levels of separation’. It is based on the integration of network science and biochemistry.