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miR‐20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells
Author(s) -
Kang Hong-Wei,
Wang Fang,
Wei Qian,
Zhao Yi-Fan,
Liu Min,
Li Xin,
Tang Hua
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.02.020
Subject(s) - downregulation and upregulation , hela , cervical cancer , cell migration , cancer research , cancer , cancer cell , cell growth , cell , cell culture , function (biology) , microbiology and biotechnology , chemistry , biology , gene , genetics
miR‐20a is an important member of the miR‐17–92 cluster, and its real function in cervical cancer cells is unknown. Our study demonstrated that miR‐20a was upregulated in cervical cancer tissues. Overexpression of miR‐20a in cervical cancer‐derived cell lines, HeLa and C‐33A, enhanced long‐term cellular proliferation, migration and invasion, whereas inhibition of miR‐20a suppressed those functions. We also confirmed that oncogenic TNKS2 is directly upregulated by miR‐20a. Furthermore, suppression of TNKS2 expression could inhibit colony formation, migration and invasion of cervical cancer cells. Therefore, we concluded that miR‐20a can promote migration and invasion of cervical cancer cells through the upregulation of TNKS2.