The  frpB1  gene of  Helicobacter pylori  is regulated by iron and encodes a membrane protein capable of binding haem and haemoglobin | Zendy

Carrizo-Chávez Miguel Angel | Zendy; Cruz-Castañeda Areli | Zendy; de Jesús Olivares-Trejo José | Zendy

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The frpB1 gene of Helicobacter pylori is regulated by iron and encodes a membrane protein capable of binding haem and haemoglobin

Author(s) -

Carrizo-Chávez Miguel Angel,

Cruz-Castañeda Areli,

de Jesús Olivares-Trejo José

Publication year - 2012

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2012.02.015

Subject(s) - helicobacter pylori , gene , biochemistry , iron binding proteins , membrane protein , chemistry , heme , hemeprotein , bacterial outer membrane , biology , membrane , microbiology and biotechnology , genetics , enzyme , escherichia coli

FrpB1 is a novel membrane protein of Helicobacter pylori that is capable of binding both haem and haemoglobin but consistently shows more affinity for haem. The mRNA levels of frpB1 were repressed by iron and lightly modulated by haem or haemoglobin. The overexpression of the frpB1 gene supported cellular growth when haem or haemoglobin were supplied as the only iron source. Three‐dimensional modelling revealed the presence of motifs necessary to bind either haem or haemoglobin. Our overall results support the idea that FrpB1 is a membrane protein of H. pylori that allows this pathogen to survive in the human stomach.

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