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MicroRNA‐203 leads to G1 phase cell cycle arrest in laryngeal carcinoma cells by directly targeting survivin
Author(s) -
Bian Ka,
Fan Jing,
Zhang Xiang,
Yang Xin-Wei,
Zhu Hua-Yu,
Wang Lei,
Sun Jian-Yong,
Meng Yan-Ling,
Cui Peng-Cheng,
Cheng Shi-Yin,
Zhang Jian,
Zhao Jing,
Yang An-Gang,
Zhang Rui
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.01.050
Subject(s) - survivin , microrna , cell cycle , cancer research , carcinoma , cell cycle checkpoint , g1 phase , chemistry , microbiology and biotechnology , biology , medicine , cell , cancer , gene , biochemistry
Previous studies have shown that miR‐203 acts as a tumor‐suppressive microRNA in various cancers, but its roles in laryngeal carcinoma are still contradicted. Here, we found that miR‐203 inhibited the growth of laryngeal cancer cells and survivin was a direct target of miR‐203. Moreover, silencing of survivin recapitulated the effect of miR‐203 on cell cycle progression, whereas overexpression of survivin reversed this effect. Additionally, qRT‐PCR showed the reciprocal relationship between miR‐203 and survivin in laryngeal cancer tissues. These findings indicate that miR‐203 inhibits the proliferation of laryngeal carcinoma cells by directly targeting survivin, suggesting its application in anti‐cancer therapeutics.