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Phosphate homeostasis in the yeast Saccharomyces cerevisiae , the key role of the SPX domain‐containing proteins
Author(s) -
Secco David,
Wang Chuang,
Shou Huixia,
Whelan James
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.01.036
Subject(s) - saccharomyces cerevisiae , yeast , homeostasis , biochemistry , phosphate , domain (mathematical analysis) , biology , microbiology and biotechnology , chemistry , computational biology , mathematical analysis , mathematics
In the yeast Saccharomyces cerevisiae , a working model for nutrient homeostasis in eukaryotes, inorganic phosphate (Pi) homeostasis is regulated by the PHO pathway, a set of phosphate starvation induced genes, acting to optimize Pi uptake and utilization. Among these, a subset of proteins containing the SPX domain has been shown to be key regulators of Pi homeostasis. In this review, we summarize the recent progresses in elucidating the mechanisms controlling Pi homeostasis in yeast, focusing on the key roles of the SPX domain‐containing proteins in these processes, as well as describing the future challenges and opportunities in this fast‐moving field.