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Inflammatory changes in adipose tissue enhance expression of GPR84, a medium‐chain fatty acid receptor
Author(s) -
Nagasaki Hiroshi,
Kondo Takaaki,
Fuchigami Masahiro,
Hashimoto Hiroyuki,
Sugimura Yoshihisa,
Ozaki Nobuaki,
Arima Hiroshi,
Ota Akira,
Oiso Yutaka,
Hamada Yoji
Publication year - 2012
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2012.01.001
Subject(s) - adipose tissue , chemistry , receptor , adiponectin , endocrinology , medicine , 3t3 l1 , cell culture , gene expression , microbiology and biotechnology , biochemistry , adipocyte , biology , insulin resistance , insulin , gene , genetics
In this study we aimed to identify the physiological roles of G protein‐coupled receptor 84 (GPR84) in adipose tissue, together with medium‐chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high‐fat diet up‐regulated GPR84 expression in fat pads. In 3T3‐L1 adipocytes, co‐culture with a macrophage cell line, RAW264, or TNFα remarkably enhanced GPR84 expression. In the presence of TNFα, MCFAs down‐regulated adiponectin mRNA expression in 3T3‐L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFα from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity.